After Christa saves a woman's life, she pleads with Neal toperform a surgery that will ensure the patient's reproductivefuture. Also, Mario gets into a fight with a patient after hedelivers a diagnosis that could imperil the man's hockeycareer.
While pursuing a gangbanger, Burgess and Roman come across thebody of an eight-year-old boy who was reported missing.Intelligence launches an investigation to find the killer andAntonio and Lindsay question a prime suspect. Meanwhile,Burgess confides in Ruzek about Roman's suspicious behavior andBunny heads to the Ivory Tower with a statement that could bedetrimental to Voight's career.
After Dre gets his yearly physical and comes home traumatized,Pops explains his generation's strong aversion towardshealthcare and admits that he hasn't seen a doctor in years.Shocked by this disclosure, Dre and Bow try to convince Popsto get a check-up and he begrudgingly agrees. When Pops findsout he has a clogged artery and needs a small procedure, therest of The Johnson family handles the news in different ways.
When a new gang, the Ghosts, hit the newly renamed StarCity, Diggle, Thea, and Laurel find themselves in over theirheads. Laurel and Thea interrupt Oliver and Felicity's quietsuburban lifestyle to ask them to come back and help.
Elliot and Alan's wedding is right around the corner, anddespite Elliot's misgivings, the couple asks Gabi to make somewhimsical appetizers for their special day. When Josh's flakyyounger brother, Jake, shows up for an unexpected visit andannounces he wants to be a chef, Josh hires him to help Gabiwith wedding prep. But as sparks fly between the two, Joshrealizes what he's done and goes to great expense to separatethe budding lovebirds. Elsewhere, Yolanda panics when shemisplaces Elliot's wedding ring while one of the grooms feelsleft out of his own nuptials. Elsewhere, Jake has a hugesurprise for Gabi.
Jimmy questions his ability as a writer but finally zeroes inon his next project. Meanwhile, Gretchen and Lindsay discoverall they do is talk about men and set out to change thestatus-quo. Edgar gets close to his improv teacher, Dorothy.
Picking up where the finale left off, Sam and Dean must dealwith the Darkness that has been unleashed. Castiel deals withthe effects of Rowena's spell and recalls his brutal battlewith Crowley.